Who might be most at risk for adverse effects from amphotericin B?

Immunocompromised patients are particularly at risk for adverse effects from amphotericin B due to their weakened immune systems. Amphotericin B is an antifungal medication used to treat severe fungal infections, but it can have significant side effects, including nephrotoxicity (kidney damage) and electrolyte imbalances. In immunocompromised individuals, the body's ability to withstand such toxicities is further diminished, leading to a higher likelihood of severe complications.

Young children, while generally at risk for medication-related side effects, may not necessarily face the same level of risk as immunocompromised patients, given that their immune systems can still provide some level of protection. Individuals with high blood pressure might experience complications if they have existing conditions worsened by heart or kidney issues, but this does not specifically relate to amphotericin B's profile compared to the broader vulnerabilities of immunocompromised individuals. Healthy adult volunteers typically would not face the same risks, as their immune systems are functional and capable of managing the medication's potential side effects.