Which medications are known to interact with ciprofloxacin? Select all that apply.

Ciprofloxacin, a fluoroquinolone antibiotic, has several known drug interactions. Phenytoin is one of the medications that can interact with ciprofloxacin. This interaction is particularly significant because ciprofloxacin can affect the metabolism of phenytoin, potentially leading to increased levels of phenytoin in the body. This could enhance the risk of toxicity from phenytoin, thereby necessitating careful monitoring of phenytoin levels when used concurrently with ciprofloxacin.

Additionally, the other medications listed may also have interactions or considerations when taken with ciprofloxacin, but they do not have the same level of documented interaction as phenytoin does. For example, ibuprofen is generally considered safe to use with ciprofloxacin, although caution is warranted as both drugs can potentially impact kidney function if taken in high doses or in patients with pre-existing kidney issues. Fluoxetine, an antidepressant, is not commonly known to produce significant interactions with ciprofloxacin. Lastly, warfarin can be influenced by ciprofloxacin, but the interaction is more monitored than critical, meaning it does require attention but is well-documented for management in clinical practice.

Understanding these interactions is crucial in a clinical setting to prevent adverse effects