Which herpes infection is NOT treated with buccal administration of acyclovir?

The use of buccal administration of acyclovir is typically reserved for certain herpes infections that are localized or more concentrated in the mucosal areas, allowing for effective absorption and targeted treatment. In the case of initial genital herpes, systemic treatment is often preferred over buccal administration. Acyclovir is more commonly given orally in higher doses for initial genital herpes to effectively combat the systemic nature of the viral outbreak and its wider distribution in the body, rather than focusing on localized treatment.

In contrast, conditions such as herpes labialis (cold sores) and herpes zoster (shingles) may be treated effectively with buccal acyclovir due to their specific sites of expression and the opportunity for localized delivery, while chickenpox often requires a more comprehensive systemic treatment approach, though it is also commonly managed through oral routes.