When taking acyclovir, which patient education statement is crucial regarding topical applications?

The statement emphasizing that patients should not use creams or lotions over the area is crucial because it highlights the importance of applying acyclovir effectively. Topical acyclovir must be absorbed into the skin to work properly against viral infections. If patients layer other creams or lotions on top, these products can create a barrier that may hinder the absorption of acyclovir, thereby reducing its efficacy. Additionally, using other topical products could irritate the skin further or cause an adverse reaction, complicating the healing process. Therefore, it's essential for patients to understand that the area should remain free from additional topical products that could interfere with the treatment.