What is the nurse's priority if a client reports side effects during amphotericin B infusion?

The priority in this scenario is to premedicate according to the provider's orders. Amphotericin B is known to cause significant side effects, especially during infusion, which may include fever, chills, rigors, nausea, and headache. Premedication typically involves administering antipyretics, antihistamines, or corticosteroids as prescribed by the healthcare provider to mitigate these side effects and enhance the client's comfort during the infusion process.

By ensuring that the client receives appropriate premedication, the nurse proactively addresses the potential adverse reactions associated with amphotericin B, improving the likelihood of a more tolerable infusion experience. This approach aligns with best practices in administering medications that are known to have significant side effects.

Terminating the infusion immediately may not be warranted unless the client is experiencing a severe reaction requiring immediate intervention, and reducing the infusion rate might not effectively alleviate the side effects. Encouraging deep breathing can be beneficial for anxiety or discomfort, but it does not directly address the side effects associated with the drug itself. Hence, premedication is the most appropriate and priority action to take.