What is Griseofulvin contraindicated for?

Griseofulvin is contraindicated in individuals with porphyria due to the drug's potential to exacerbate the condition. Porphyrias are a group of disorders caused by an overaccumulation of porphyrins or porphyrin precursors, which are essential for the production of heme. Griseofulvin can interfere with heme synthesis, potentially leading to a worsening of symptoms such as abdominal pain, neuropathy, or skin problems associated with porphyria. Because of this interaction, patients with this condition should avoid using griseofulvin.

In terms of the other options, while patients with diabetes, those who are pregnant, or individuals with cardiac issues may need careful consideration when prescribed various medications, griseofulvin is specifically contraindicated in the case of porphyria due to its direct effects on heme metabolism.