What is an appropriate intervention before administering an infusion of amphotericin B?

Administering an antipyretic and an antiemetic drug before the infusion of amphotericin B is an important intervention because this antifungal medication is known to cause several side effects, particularly during the initial administration. Patients often experience symptoms such as fever, chills, nausea, and vomiting. By premedicating with an antipyretic, such as acetaminophen, and an antiemetic, like ondansetron, healthcare providers can help mitigate these potential reactions and improve the patient's comfort throughout the infusion process.

This proactive approach reduces the likelihood of severe adverse reactions during the infusion and ensures that the patient can tolerate the treatment better. Therefore, the choice to premedicate with these types of medications is supported by clinical guidelines and aims to enhance patient safety and overall treatment adherence.