What is a common adverse effect associated with amphotericin B?

Amphotericin B is an antifungal medication widely used to treat serious fungal infections. One of the well-documented adverse effects associated with this drug is nephrotoxicity, which refers to kidney damage or impairment. This occurs because amphotericin B can cause constriction of the afferent arterioles in the kidneys, leading to decreased renal blood flow and impaired kidney function.

Monitoring kidney function is crucial during treatment with amphotericin B, and clinicians often assess serum creatinine levels to evaluate renal integrity. Preventive measures, such as hydration and the use of lipid formulations of the drug known to have less nephrotoxic potential, may be employed to mitigate this adverse effect.

In contrast, options like increased appetite, headaches, and insomnia are not commonly associated side effects of amphotericin B, making nephrotoxicity the most relevant concern when considering the safety profile of this medication.