Isoniazid (INH) and rifampin have adverse effects that impact the __________ while ethambutol has adverse effects that impact the __________.

Isoniazid (INH) and rifampin are both medications used in the treatment of tuberculosis, and one of their significant adverse effects is hepatotoxicity, which can lead to liver injury. This makes it essential for healthcare providers to monitor liver function in patients taking these drugs.

On the other hand, ethambutol is primarily associated with ocular side effects, specifically optic neuritis, which can lead to vision changes or loss. This highlights the need for eye examinations and monitoring of visual acuity in patients receiving ethambutol therapy.

Therefore, the correct pairing indicates that isoniazid and rifampin adversely affect the liver, while ethambutol adversely affects the eyes. This distinction is crucial for understanding the implications of these medications in treatment protocols and for ensuring patient safety through appropriate monitoring.