In which condition is Voriconazole contraindicated?

Voriconazole is an antifungal medication commonly used to treat serious fungal infections. Its use during pregnancy is contraindicated primarily due to potential risks to the developing fetus. Animal studies have shown teratogenic effects, which means it could cause developmental abnormalities. As such, the potential benefits of using Voriconazole in a pregnant patient do not outweigh the risks, leading to a recommendation against its use in this population.

On the other hand, while caution is warranted in patients with kidney and liver failure since these conditions can affect drug metabolism and clearance, Voriconazole is still used in certain contexts under careful monitoring. In cases of heart disease, there are no specific contraindications to Voriconazole use, although caution is suggested if other comorbidities are present. Thus, the strong emphasis on avoiding Voriconazole during pregnancy highlights its significant risk profile in this circumstance.