For which new medication prescribed for a client taking acyclovir should the nurse seek clarification?

When considering the interactions and effects of medications prescribed to a client taking acyclovir, probenecid is particularly noteworthy. Probenecid is known to inhibit the renal excretion of certain drugs, including acyclovir. This can lead to elevated levels of acyclovir in the bloodstream, increasing the risk of toxicity and side effects. Given that acyclovir is primarily eliminated through the kidneys, introducing probenecid without careful monitoring can be potentially harmful.

In contrast, medications like ibuprofen, hydrochlorothiazide, and simvastatin do not have the same level of interaction with acyclovir. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) and can be safely used for pain relief or inflammation without directly affecting the metabolism or clearance of acyclovir. Hydrochlorothiazide is a thiazide diuretic, which may be prescribed for hypertension or fluid retention, and is also not known to interfere with acyclovir's safety profile. Simvastatin, as a statin used for lowering cholesterol, operates through different metabolic pathways and doesn't affect acyclovir clearance.

Hence, the nurse should seek clarification for probenecid in this scenario due to its potential impact on acyclovir