Antitubercular treatment can impact which of the following organs/systems?

Antitubercular treatment primarily impacts various organs and systems as a result of the medications used to treat tuberculosis (TB). The correct choice relates specifically to the eye, liver, and peripheral nervous system.

The liver is significantly affected because many antitubercular medications, such as isoniazid and rifampicin, can be hepatotoxic, leading to liver injury or dysfunction. Regular monitoring of liver function tests is essential during TB treatment to avoid severe liver damage.

Additionally, ocular complications can arise from certain medications. For instance, ethambutol is known to potentially cause visual disturbances, particularly affecting the optic nerve. This is why monitoring visual acuity during treatment can be crucial.

The peripheral nervous system can also be impacted, particularly by isoniazid, which can lead to peripheral neuropathy, especially in individuals who may have preexisting conditions or are deficient in vitamin B6. Supplementation of pyridoxine (vitamin B6) is frequently recommended alongside isoniazid to mitigate this risk.

These systemic effects highlight the complex interactions between antitubercular drugs and various organs, emphasizing the importance of vigilant monitoring and patient education during treatment.