A client is receiving isoniazid (INH) and has been taking vitamin B12. The healthcare provider suggests changing it to which vitamin?

The correct choice is Vitamin B6, also known as pyridoxine. When a patient is taking isoniazid (INH) as a treatment for tuberculosis, one of the known side effects of this medication is the potential for peripheral neuritis, which can be exacerbated by a deficiency in Vitamin B6. Isoniazid can interfere with the metabolism of Vitamin B6, which plays a crucial role in nerve function and the synthesis of neurotransmitters.

Supplementing with Vitamin B6 can help mitigate these side effects and prevent neuropathy in patients receiving isoniazid. This is a well-recognized recommendation in clinical practice to promote neurological health in patients undergoing treatment for tuberculosis.

Other vitamins listed, such as B1 (thiamine), B2 (riboflavin), and C (ascorbic acid), do not address the specific side effects caused by isoniazid and therefore are not suitable substitutes in this scenario.